![Read more about the article [Paper Review #9] Chemogenetic Control of Nanobodies](https://pharmphd.com/wp-content/uploads/2026/02/image-6.avif)
https://www.nature.com/articles/s41592-020-0746-7 Chemogenetic Control of Nanobodies Key figures [Fig. 1]: Defines the LAMA design principle (cpDHFR insertion into nanobody CDRs) and demonstrates ligand-triggered loss of target binding with reversible kinetics and…
![Read more about the article [Paper Review #8] Direct control of CAR T cells through small molecule-regulated antibodies](https://pharmphd.com/wp-content/uploads/2026/02/image-5.avif)
https://www.nature.com/articles/s41467-020-20671-6 Direct control of CAR T cells through small molecule-regulated antibodies Key figures [Figure 3]: Establishes that a single-module “conditional CAR” retains potent target killing yet is reversibly and dose-dependently…
![Read more about the article [Paper Review #7] Rational design of small-molecule responsive protein switches](https://pharmphd.com/wp-content/uploads/2026/02/image-4.avif)
https://onlinelibrary.wiley.com/doi/10.1002/pro.4774 Rational design of small-molecule responsive protein switches Key figures [Figure 3]: Lays out computationally designed switch architectures (CID, CDH, AIR) and the design logic (motif grafting, interface design, multi-state…
![Read more about the article [Paper Review #6] Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins](https://pharmphd.com/wp-content/uploads/2026/02/image-3.avif)
https://www.nature.com/articles/s41467-024-50235-x Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins Key figures Fig. 5: Establishes the lead K1 LNP formulation achieving near-complete GFP-KRAS clearance plus dose…
![Read more about the article [Paper Review #5] Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems](https://pharmphd.com/wp-content/uploads/2026/02/image-2.avif)
https://pubs.acs.org/doi/10.1021/acschembio.2c00518 Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems Key figures [Figure 3B]: Quantitatively shows C12’s markedly lower basal abundance while preserving…
![Read more about the article [Paper Review #4] The dTAG system for immediate and target-specific protein degradation](https://pharmphd.com/wp-content/uploads/2026/02/image-1.avif)
https://www.nature.com/articles/s41589-018-0021-8 The dTAG system for immediate and target-specific protein degradation Key figures [Fig. 1]: Establishes the core chemical-genetic mechanism—FKBP12F36V-selective engagement plus CRBN recruitment and ternary complex formation (including the “hook…
![Read more about the article [Paper Review #3] Inhibitory probes for spatiotemporal analysis of Gαs protein signaling](https://pharmphd.com/wp-content/uploads/2026/02/image.avif)
https://www.nature.com/articles/s41589-025-02138-1 Inhibitory probes for spatiotemporal analysis of Gαs protein signaling Key figures [Fig. 3a]: Demonstrates compartment-selective inhibition (endo-targeted inhibitor suppresses the sustained endosomal cAMP phase while sparing the early plasma-membrane…
Pooled CRISPR Screen & Arrayed CRISPR Screen
![Read more about the article [Paper Review #2] Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii](https://pharmphd.com/wp-content/uploads/2024/09/image-26.png)
Paper Review #2
![Read more about the article [Paper Review #1] De novo design of peptides that bind specific conformers of ⍺-synuclein](https://pharmphd.com/wp-content/uploads/2024/09/image-10.png)
Paper Review #1