[Paper Review #32] Biomolecular design through latent reasoning with RFD4-Proteina
Corley et al., Author-hosted preprint (not peer reviewed), 2026
0 Comments
October 23, 2026
![Read more about the article [Paper Review #32] Biomolecular design through latent reasoning with RFD4-Proteina](https://pharmphd.com/wp-content/uploads/2026/10/pharmphd-7993efeebcaafaf9e840.avif)
![Read more about the article [Paper Review #31] Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)](https://pharmphd.com/wp-content/uploads/2026/10/pharmphd-f48bc14b4ae15cf5078e.avif)
[Paper Review #31] Deep-learning-based design of an orthogonal self-labeling protein from K-Ras(G12C)
Mou et al., bioRxiv, 2026 | Preprint
October 21, 2026
![Read more about the article [Paper Review #30] Zero-shot design of drug-binding proteins via neural iterative selection−expansion](https://pharmphd.com/wp-content/uploads/2026/07/image-9.avif)
[Paper Review #30] Zero-shot design of drug-binding proteins via neural iterative selection−expansion
Fry et al., Nature, 2026 | PMID: 42343133
July 16, 2026
![Read more about the article [Paper Review #29] The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics](https://pharmphd.com/wp-content/uploads/2026/07/image-7.avif)
[Paper Review #29] The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics
Islam, Cell Chemical Biology, 2018 | PMID: 30078633
July 10, 2026
![Read more about the article [Paper Review #28] Improving de novo protein binder design with deep learning](https://pharmphd.com/wp-content/uploads/2026/07/image-6-scaled.avif)
[Paper Review #28] Improving de novo protein binder design with deep learning
Bennett et al., Nature Communications, 2023 | PMID: 37149653
July 10, 2026
![Read more about the article [Paper Review #27] Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes](https://pharmphd.com/wp-content/uploads/2026/07/image-5-scaled.avif)
[Paper Review #27] Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes
Jung et al., IUBMB Life, 2026 | PMID: 42287093
July 10, 2026
![Read more about the article [Paper Review #26] Computational design of conformation-biasing mutations to alter protein functions](https://pharmphd.com/wp-content/uploads/2026/07/image-4.avif)
[Paper Review #26] Computational design of conformation-biasing mutations to alter protein functions
Cavanagh et al., Science, 2026 | PMID: 41505504
July 10, 2026
![Read more about the article [Paper Review #25] Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs](https://pharmphd.com/wp-content/uploads/2026/06/image-3.avif)
[Paper Review #25] Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs
Sadagopan et al., Nature Chemical Biology, 2025 | PMID: 41184486
June 9, 2026
![Read more about the article [Paper Review #24] Discovery of Covalent Ligands with AlphaFold3](https://pharmphd.com/wp-content/uploads/2026/06/image-2-scaled.avif)
[Paper Review #24] Discovery of Covalent Ligands with AlphaFold3
Shamir et al., Journal of the American Chemical Society, 2026 | PMID: 41857796
June 9, 2026
![Read more about the article [Paper Review #23] De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries](https://pharmphd.com/wp-content/uploads/2026/05/image-5.avif)
[Paper Review #23] De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries
Li et al., Proceedings of the National Academy of Sciences, 2022 | PMID: 36534810
May 31, 2026