![Read more about the article [Paper Review #5] Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems](https://pharmphd.com/wp-content/uploads/2026/02/image-2.avif)
https://pubs.acs.org/doi/10.1021/acschembio.2c00518 Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems Key figures [Figure 3B]: Quantitatively shows C12’s markedly lower basal abundance while preserving…
![Read more about the article [Paper Review #4] The dTAG system for immediate and target-specific protein degradation](https://pharmphd.com/wp-content/uploads/2026/02/image-1.avif)
https://www.nature.com/articles/s41589-018-0021-8 The dTAG system for immediate and target-specific protein degradation Key figures [Fig. 1]: Establishes the core chemical-genetic mechanism—FKBP12F36V-selective engagement plus CRBN recruitment and ternary complex formation (including the “hook…
![Read more about the article [Paper Review #3] Inhibitory probes for spatiotemporal analysis of Gαs protein signaling](https://pharmphd.com/wp-content/uploads/2026/02/image.avif)
https://www.nature.com/articles/s41589-025-02138-1 Inhibitory probes for spatiotemporal analysis of Gαs protein signaling Key figures [Fig. 3a]: Demonstrates compartment-selective inhibition (endo-targeted inhibitor suppresses the sustained endosomal cAMP phase while sparing the early plasma-membrane…
Pooled CRISPR Screen & Arrayed CRISPR Screen
![Read more about the article [Paper Review #2] Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii](https://pharmphd.com/wp-content/uploads/2024/09/image-26.png)
Paper Review #2
![Read more about the article [Paper Review #1] De novo design of peptides that bind specific conformers of ⍺-synuclein](https://pharmphd.com/wp-content/uploads/2024/09/image-10.png)
Paper Review #1