https://www.nature.com/articles/s41592-020-0746-7 Chemogenetic Control of Nanobodies Key figures [Fig. 1]: Defines the LAMA design principle (cpDHFR insertion into nanobody CDRs) and demonstrates ligand-triggered loss of target binding with reversible kinetics and…

https://www.nature.com/articles/s41467-020-20671-6 Direct control of CAR T cells through small molecule-regulated antibodies Key figures [Figure 3]: Establishes that a single-module “conditional CAR” retains potent target killing yet is reversibly and dose-dependently…

https://onlinelibrary.wiley.com/doi/10.1002/pro.4774 Rational design of small-molecule responsive protein switches Key figures [Figure 3]: Lays out computationally designed switch architectures (CID, CDH, AIR) and the design logic (motif grafting, interface design, multi-state…

https://www.nature.com/articles/s41467-024-50235-x Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins Key figures Fig. 5: Establishes the lead K1 LNP formulation achieving near-complete GFP-KRAS clearance plus dose…

https://pubs.acs.org/doi/10.1021/acschembio.2c00518 Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems Key figures [Figure 3B]: Quantitatively shows C12’s markedly lower basal abundance while preserving…

https://www.nature.com/articles/s41589-018-0021-8 The dTAG system for immediate and target-specific protein degradation Key figures [Fig. 1]: Establishes the core chemical-genetic mechanism—FKBP12F36V-selective engagement plus CRBN recruitment and ternary complex formation (including the “hook…

https://www.nature.com/articles/s41589-025-02138-1 Inhibitory probes for spatiotemporal analysis of Gαs protein signaling Key figures [Fig. 3a]: Demonstrates compartment-selective inhibition (endo-targeted inhibitor suppresses the sustained endosomal cAMP phase while sparing the early plasma-membrane…