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https://www.nature.com/articles/s41589-018-0021-8 The dTAG system for immediate and target-specific protein degradation Key figures [Fig. 1]: Establishes the core chemical-genetic mechanism—FKBP12F36V-selective engagement plus CRBN recruitment and ternary complex formation (including the “hook…
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https://www.nature.com/articles/s41589-025-02138-1 Inhibitory probes for spatiotemporal analysis of Gαs protein signaling Key figures [Fig. 3a]: Demonstrates compartment-selective inhibition (endo-targeted inhibitor suppresses the sustained endosomal cAMP phase while sparing the early plasma-membrane…
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