https://www.nature.com/articles/s41467-021-25735-9 A rational blueprint for the design of chemically-controlled protein switches Key figures [Figure 4]: It is the central conceptual advance because it shows how OFF-switch CDHs were converted into…

https://www.biorxiv.org/content/10.64898/2026.03.03.707476v1 Explainable Physicochemical Determinants of Protein–Ligand Binding via Non-Covalent Interactions Key figures [Figure 1]: Establishes the main contribution by pairing InteractBind dataset construction with ExplainBind’s attention-supervised sequence model, making the…

https://www.pnas.org/doi/10.1073/pnas.1911154117 A conformation-specific ON-switch for controlling CAR T cells with an orally available drug Key figures [Figure 2E]: Quantifies drug-dependent dynamic range (nanomolar ON vs micromolar OFF) and cross-validates switching…

https://www.nature.com/articles/s41592-020-0746-7 Chemogenetic Control of Nanobodies Key figures [Fig. 1]: Defines the LAMA design principle (cpDHFR insertion into nanobody CDRs) and demonstrates ligand-triggered loss of target binding with reversible kinetics and…

https://www.nature.com/articles/s41467-020-20671-6 Direct control of CAR T cells through small molecule-regulated antibodies Key figures [Figure 3]: Establishes that a single-module “conditional CAR” retains potent target killing yet is reversibly and dose-dependently…

https://onlinelibrary.wiley.com/doi/10.1002/pro.4774 Rational design of small-molecule responsive protein switches Key figures [Figure 3]: Lays out computationally designed switch architectures (CID, CDH, AIR) and the design logic (motif grafting, interface design, multi-state…

https://www.nature.com/articles/s41467-024-50235-x Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins Key figures Fig. 5: Establishes the lead K1 LNP formulation achieving near-complete GFP-KRAS clearance plus dose…