https://www.nature.com/articles/s41598-025-20608-3 Structural determination of small proteins by cryo-EM using a coiled coil module strategy Key figures Figure 1: Explains the APH2 coiled-coil fusion design, including direct shared-helix fusion in CC2…

https://www.nature.com/articles/s41587-026-03081-9 Artificial allosteric protein switches with machine-learning-designed receptors Key figures Figure 1: Shows that circularly permuted natural and machine-learning-designed receptor domains can drive ligand-dependent activation of a β-lactamase reporter without…

https://www.science.org/doi/10.1126/science.adr7094 Deep learning–guided design of dynamic proteins Key figures Figure 1: Explains the full design workflow, from de novo generation of alternative states through deep learning–guided multistate design to mutation-based…

https://onlinelibrary.wiley.com/doi/10.1002/pro.2610 Rapid search for tertiary fragments reveals protein sequence–structure relationships Key figures Figure 1: Explains the core MASTER algorithm, showing how partial alignments constrain the allowed locations of remaining segments…

https://www.nature.com/articles/s41467-022-28507-1 Defining molecular glues with a dual-nanobody cannabidiol sensor Key figures Figure 6: Extends the CBD and auxin logic to canonical IMiD systems by showing that CRBN already has measurable…